Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota. Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota. Department of Health Science Research, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota; Department of Neurology, Mayo Clinic, Rochester, Minnesota. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota; Department of Neurology, Mayo Clinic, Rochester, Minnesota. Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota; Departments of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota. Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota; Department of Pediatric and Adolescent Medicine (Division of Pediatric Cardiology), Mayo Clinic, Rochester, Minnesota; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota. Electronic address: ackerman.michael@mayo.edu.